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Cancer genetics
Review
Advances in research on the mechanism of tsRNA action in tumours
  1. Yan Gao1,
  2. Yanzhao Huang2,
  3. Kaiyun Guo1,
  4. Jun Cheng1,
  5. Yuting Luo3,
  6. Yi Deng1,
  7. Ming Lei1
  1. 1 The First People's Hospital of Changde City, Changde, Hunan, China
  2. 2 Hengyang Medical College, Hengyang, Hunan, China
  3. 3 Hunan University of Arts and Science, Changde, Hunan, China
  1. Correspondence to Professor Ming Lei; 285928388{at}csu.edu.cn; Dr Yi Deng; 876264674{at}qq.com

Abstract

tsRNA is a class of non-coding RNAs derived from mature or precursor tRNAs. In recent years, more and more studies have explored the correlation between tsRNAs and tumours. tsRNAs can affect the biological behaviours of tumour cells such as proliferation, apoptosis and metastasis by regulating gene expression, protein translation or post-transcriptional regulation. In this paper, we systematically review the production, biological function and research progress of tsRNA in tumour and discuss its prospects as biomarkers and therapeutic targets.

  • Genetic Association Studies

https://doi.org/10.1136/jmg-2024-110437

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    Footnotes

    • YG and YH contributed equally.

    • Contributors YG wrote the original manuscript. YH was responsible for conducting literature review and editing. KG was responsible for creating figures and tables. JC designed and revised the manuscript. YL was responsible for editing. YD was responsible for structural design and reviewing. ML determined the topic scope and reviewing. ML is the guarantor.

    • Funding This work was supported by Natural Science Foundation of Hunan Province (No.2024JJ7018), Health Research Project of Hunan Provincial Health Commission (202103011014) and Project of Hunan Provincial Department of Education (22C0389).

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.