| Relationship to patient with CD | Smoking status | Risk (%) related to number of CARD15 mutations | |||
| 0 | 1 | 2 | Not genotyped | ||
| Sibling | Non-smokers | 1.9 | 4.2 | 17.5 | 2.2 |
| Smokers | 3.8 | 8.5 | 35.0 | 4.4 | |
| Unknown | 2.3 | 5.3 | 21.7 | 2.7 | |
| Offspring | Non-smokers | 1.2 | 2.6 | 10.7 | 1.3 |
| Smokers | 2.3 | 5.2 | 21.4 | 2.7 | |
| Unknown | 1.4 | 3.2 | 13.2 | 1.7 | |
| Parents | Non-smokers | 0.9 | 2.0 | 8.2 | 1.0 |
| Smokers | 1.8 | 4.0 | 16.5 | 2.1 | |
| Unknown | 1.1 | 2.5 | 10.2 | 1.3 | |
Estimated from risk model, by relationship to patient with CD (sibling, offspring, parent), by smoking status and by CARD15 genotype.