Cancer risk estimates for gastric and breast cancer in CDH1 probands
| (A) Penetrance model parameter estimates | ||||||
| Male | Female | |||||
| Age group | Log (RR) | SE | RR | Log (RR) | SE | RR |
| Gastric cancer | ||||||
| 20–44 | 3.65 | 0.94 | 38.47 | 4.40 | 0.93 | 81.77 |
| 45–59 | 3.49 | 0.98 | 32.85 | 3.49 | 0.98 | 32.90 |
| 60–85 | 3.44 | 1.04 | 31.28 | 3.45 | 1.05 | 31.37 |
| Breast cancer | ||||||
| 20–85 | – | – | – | 1.50 | 0.20 | 4.48 |
| 20–49 | – | – | – | 1.84 | 0.17 | 6.32 |
| 50+ | – | – | – | 1.33 | 0.21 | 3.79 |
| (B) Cumulative risk | ||||||
| Age group | Male (%) | Female (%) | ||||
| Gastric cancer | Risk (%) | 95% CI (%) | Risk (%) | 95% CI (%) | ||
| 20–29 | 0.3 | 0.0 | 1.2 | 0.7 | 0.1 | 2.6 |
| 30–39 | 1.3 | 0.1 | 5.3 | 2.8 | 0.3 | 10.8 |
| 40–49 | 4.1 | 0.8 | 13.1 | 5.5 | 1.0 | 17.5 |
| 50–59 | 10.6 | 2.4 | 31.7 | 8.9 | 2.1 | 25.4 |
| 60–69 | 22.7 | 5.5 | 61.9 | 15.3 | 4.1 | 41.6 |
| 70–79 | 37.2 | 8.7 | 89.5 | 24.7 | 6.1 | 68.9 |
| Breast cancer female | Risk (%) | 95% CI (%) | ||||
| 20–29 | 0.5 | 0.4 | 0.7 | |||
| 30–39 | 3.9 | 2.8 | 5.3 | |||
| 40–49 | 13.0 | 9.7 | 17.3 | |||
| 50–59 | 21.2 | 16.6 | 26.6 | |||
| 60–69 | 32.2 | 25.1 | 40.7 | |||
| 70–79 | 42.9 | 33.4 | 53.9 | |||
RR, relative risk.