Associations of CDH1 germline variant location and cancer phenotype in families with hereditary diffuse gastric cancer (HDGC)

Winifred Lo; Bin Zhu; Arvind Sabesan; Ho-Hsiang Wu; Astin Powers; Rebecca A Sorber; Sarangan Ravichandran; Ina Chen; Lucas A McDuffie; Humair S Quadri; Joal D Beane; Kathleen Calzone; Markku M Miettinen; Stephen M Hewitt; Christopher Koh; Theo Heller; Sholom Wacholder; Udo Rudloff

doi:10.1136/jmedgenet-2018-105361

Article info

Genotype-phenotype correlations

Original article

Associations of CDH1 germline variant location and cancer phenotype in families with hereditary diffuse gastric cancer (HDGC)

Authors

Winifred Lo Thoracic and Surgical Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Bin Zhu Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA PubMed articles Google scholar articles
Arvind Sabesan Thoracic and Surgical Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Ho-Hsiang Wu Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA PubMed articles Google scholar articles
Astin Powers Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Rebecca A Sorber Thoracic and Surgical Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA PubMed articles Google scholar articles
Sarangan Ravichandran Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA PubMed articles Google scholar articles
Ina Chen Thoracic and Surgical Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA PubMed articles Google scholar articles
Lucas A McDuffie Thoracic and Surgical Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA PubMed articles Google scholar articles
Humair S Quadri Thoracic and Surgical Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA Department of Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia, USA PubMed articles Google scholar articles
Joal D Beane Thoracic and Surgical Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA PubMed articles Google scholar articles
Kathleen Calzone Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Markku M Miettinen Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Stephen M Hewitt Experimental Pathology Laboratory, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles
Christopher Koh Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA PubMed articles Google scholar articles
Theo Heller Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA PubMed articles Google scholar articles
Sholom Wacholder Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA PubMed articles Google scholar articles
Udo Rudloff Thoracic and Surgical Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA Rare Tumor Initiative, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA PubMed articles Google scholar articles

Correspondence to Dr Udo Rudloff, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; rudloffu{at}mail.nih.gov

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Citation

Lo W, Zhu B, Sabesan A, et al

Associations of CDH1 germline variant location and cancer phenotype in families with hereditary diffuse gastric cancer (HDGC)

Journal of Medical Genetics 2019;56:370-379.

Publication history

Received March 1, 2018
Revised December 11, 2018
Accepted January 3, 2019
First published February 11, 2019.

Online issue publication

May 28, 2019

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